{
  "schemaVersion": 1,
  "slug": "sesca",
  "name": "sesca",
  "description": "Predict a protein's far-UV circular dichroism spectrum from a PDB structure with SESCA, or deconvolute a measured CD spectrum into helix, sheet and coil fractions — basis-set choice, mean residue ellipticity units, and the silent-failure traps.",
  "category": "analysis",
  "version": "1.0.0",
  "author": "Heureka Labs",
  "license": "CC-BY-4.0",
  "tags": [
    "circular-dichroism",
    "secondary-structure",
    "protein-structure",
    "protein-design",
    "spectroscopy"
  ],
  "covers": [
    "circular dichroism",
    "CD spectrum",
    "CD spectroscopy",
    "far-UV CD",
    "SRCD",
    "synchrotron radiation circular dichroism",
    "secondary structure estimation",
    "secondary structure content",
    "CD deconvolution",
    "CD prediction",
    "mean residue ellipticity",
    "MRE",
    "kMRE",
    "delta epsilon",
    "millidegrees",
    "alpha helix",
    "beta sheet",
    "random coil",
    "basis spectra",
    "DISICL",
    "DSSP",
    "HBSS",
    "model validation",
    "folded check",
    "designed protein",
    "intrinsically disordered",
    "Bayesian secondary structure",
    "lysozyme",
    "myoglobin"
  ],
  "papers": [
    "doi:10.1021/acs.jctc.9b00203",
    "doi:10.1007/s00249-020-01457-6",
    "doi:10.1016/j.cpc.2021.108022"
  ],
  "updatedAt": "2026-10-21T21:23:30-04:00",
  "source": {
    "repo": "heurekalabsco/heurekaskills",
    "commit": "3ca5c00a134bf070f284dffd5c27330a4d02df34",
    "path": "skills/sesca"
  },
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  "signals": null,
  "files": [
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      "path": "SKILL.md",
      "url": "https://heurekaskills.com/sesca/files/SKILL.md",
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}