{
  "schemaVersion": 1,
  "slug": "omega",
  "name": "omega",
  "description": "Fragment designed genes into orderable oligopool subpools with OMEGA — place Golden Gate junctions by simulated annealing against measured ligation fidelity, check every gene reassembles in silico, and emit the oligos to order.",
  "category": "utility",
  "version": "1.0.0",
  "author": "Heureka Labs",
  "license": "CC-BY-4.0",
  "tags": [
    "golden-gate",
    "oligopool",
    "library-design",
    "dna-assembly",
    "protein-engineering"
  ],
  "covers": [
    "oligopool",
    "oligo pool",
    "gene library",
    "golden gate",
    "type IIS",
    "BsaI",
    "BsmBI",
    "BbsI",
    "overhang fidelity",
    "junction",
    "subpool",
    "gene synthesis",
    "gene assembly",
    "fragment design",
    "variant library",
    "designed proteins",
    "GFP library",
    "oligo order",
    "T4 ligase",
    "simulated annealing"
  ],
  "papers": [
    "doi:10.1126/sciadv.ady2279",
    "doi:10.1021/acssynbio.8b00333",
    "doi:10.1371/journal.pone.0238592",
    "doi:10.1093/synbio/ysx008"
  ],
  "updatedAt": "2026-10-20T08:11:59-04:00",
  "source": {
    "repo": "heurekalabsco/heurekaskills",
    "commit": "87bef344c860de2523de46617b1f9e4d0a34c5ac",
    "path": "skills/omega"
  },
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  "signals": null,
  "files": [
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      "path": "SKILL.md",
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