{
  "schemaVersion": 1,
  "slug": "impc",
  "name": "impc",
  "description": "Query IMPC / KOMP2 mouse knockout phenotypes over the EBI Solr API — Mammalian Phenotype calls for ~8,000 knocked-out genes with p-values, effect sizes, zygosity, sex and phenotyping centre, plus the separate viability and fertility screens that say whether the homozygote survives. Resolves a human gene to its mouse ortholog, and distinguishes never tested from tested and normal.",
  "category": "data",
  "version": "1.0.0",
  "author": "Heureka Labs",
  "license": "CC-BY-4.0",
  "tags": [
    "impc",
    "mouse",
    "knockout",
    "phenotyping",
    "public-data"
  ],
  "covers": [
    "impc",
    "komp",
    "komp2",
    "mouse",
    "mus musculus",
    "knockout mouse",
    "null allele",
    "loss of function",
    "gene function",
    "essential genes",
    "embryonic lethality",
    "preweaning lethality",
    "viability",
    "fertility",
    "infertility",
    "mammalian phenotype ontology",
    "deafness",
    "hearing",
    "obesity",
    "body fat",
    "bone mineral density",
    "glucose tolerance",
    "retina",
    "behaviour",
    "grip strength",
    "clinical chemistry",
    "haematology",
    "dysmorphology",
    "ortholog",
    "sexual dimorphism"
  ],
  "papers": [
    "PMID:27626380",
    "PMID:36305825",
    "PMID:41231752",
    "PMID:35944064",
    "PMID:33378393",
    "PMID:31591642"
  ],
  "access": [
    "open"
  ],
  "updatedAt": "2026-08-27T10:40:18-04:00",
  "source": {
    "repo": "heurekalabsco/heurekaskills",
    "commit": "39b38602c74abeb725438a3906d881fcba5f3cd6",
    "path": "skills/impc"
  },
  "checksum": "sha256:d05808c5090f02968fa1234fc4dba4d7e681217c29dd46535236f45a2a36c077",
  "signals": null,
  "files": [
    {
      "path": "SKILL.md",
      "url": "https://heurekaskills.com/impc/files/SKILL.md",
      "size": 60945,
      "sha256": "39fbe1aff842a30a4e59c48935cb3232d38c98a0f53e94219c3b9460e2a026e7"
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  ]
}