{
  "schemaVersion": 1,
  "slug": "depmap",
  "name": "depmap",
  "description": "Retrieve DepMap cancer dependency data pinned to a named quarterly release — CRISPR gene effect (Chronos), expression, copy number, mutations, drug sensitivity and cell-line annotation across ~1,178 models. Resolves a release name to a citable, versioned figshare record, because gene effect scores move between quarters and an unpinned analysis is not reproducible.",
  "category": "data",
  "version": "1.0.0",
  "author": "Heureka Labs",
  "license": "CC-BY-4.0",
  "tags": [
    "depmap",
    "crispr",
    "cancer",
    "multi-omics",
    "public-data"
  ],
  "covers": [
    "depmap",
    "achilles",
    "ccle",
    "crispr knockout screen",
    "chronos",
    "gene effect",
    "gene dependency",
    "common essential",
    "synthetic lethality",
    "cancer cell line",
    "cell line encyclopedia",
    "oncotree",
    "lung",
    "breast",
    "bowel",
    "colorectal",
    "ovary",
    "skin",
    "melanoma",
    "lymphoid",
    "leukemia",
    "brain",
    "pancreas",
    "prostate",
    "kidney",
    "copy number",
    "somatic mutation",
    "gene expression",
    "drug sensitivity",
    "human"
  ],
  "papers": [
    "PMID:28753430",
    "PMID:29083409",
    "PMID:34930405",
    "PMID:32613204",
    "PMID:31068700",
    "PMID:30971826",
    "doi:10.1186/s13059-024-03336-1"
  ],
  "access": [
    "open"
  ],
  "updatedAt": "2026-08-27T10:45:01-04:00",
  "source": {
    "repo": "heurekalabsco/heurekaskills",
    "commit": "39b38602c74abeb725438a3906d881fcba5f3cd6",
    "path": "skills/depmap"
  },
  "checksum": "sha256:9e29da637e756ca9fa57277edd9f66c58f90a72fa473e6528de09cdcd3912943",
  "signals": null,
  "files": [
    {
      "path": "SKILL.md",
      "url": "https://heurekaskills.com/depmap/files/SKILL.md",
      "size": 58038,
      "sha256": "65f767e294342d51b6e4cfe3a916f0acaaf22e4867dd0a26a8e08a1d3748002d"
    }
  ]
}