{
  "schemaVersion": 1,
  "slug": "caliby",
  "name": "caliby",
  "description": "Design protein sequences against a structural ensemble rather than one backbone with Caliby — a Potts model whose parameters average across conformers, so one sequence is optimised for all of them at once. Covers where ensembles come from, what the energy means, and the silent ways the molecule Caliby designs stops being the molecule you handed it.",
  "category": "models",
  "version": "1.0.0",
  "author": "Heureka Labs",
  "license": "CC-BY-4.0",
  "tags": [
    "protein-design",
    "inverse-folding",
    "protein-structure",
    "caliby"
  ],
  "updatedAt": "2026-08-29T00:38:00-04:00",
  "source": {
    "repo": "heurekalabsco/heurekaskills",
    "commit": "a489ab0a3533363928f0f0f65e2b9df98ec8a933",
    "path": "skills/caliby"
  },
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  "signals": null,
  "files": [
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      "path": "SKILL.md",
      "url": "https://heurekaskills.com/caliby/files/SKILL.md",
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