{
  "schemaVersion": 1,
  "slug": "biophi",
  "name": "biophi",
  "description": "Humanise murine antibody variable domains with BioPhi's Sapiens model and score humanness as OASis identity — covers the bioconda-only install, the 21 GiB peptide database and the lighter route around it.",
  "category": "models",
  "version": "1.0.0",
  "author": "Heureka Labs",
  "license": "CC-BY-4.0",
  "tags": [
    "antibody",
    "humanization",
    "protein-language-model",
    "protein-engineering"
  ],
  "covers": [
    "antibody humanization",
    "humanisation",
    "murine antibody",
    "mouse antibody",
    "chimeric antibody",
    "Sapiens",
    "OASis",
    "humanness",
    "immunogenicity",
    "anti-drug antibody",
    "antibody language model",
    "variable domain",
    "VH",
    "VL",
    "Fab",
    "nanobody",
    "VHH",
    "CDR grafting",
    "back-mutation",
    "germline",
    "therapeutic antibody",
    "biologics",
    "Observed Antibody Space",
    "9-mer peptide",
    "Kabat",
    "framework",
    "OKT3",
    "teplizumab"
  ],
  "papers": [
    "PMID:35133949",
    "PMID:15136729"
  ],
  "updatedAt": "2026-10-21T16:01:48-04:00",
  "source": {
    "repo": "heurekalabsco/heurekaskills",
    "commit": "87bef344c860de2523de46617b1f9e4d0a34c5ac",
    "path": "skills/biophi"
  },
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  "signals": null,
  "files": [
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      "path": "SKILL.md",
      "url": "https://heurekaskills.com/biophi/files/SKILL.md",
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