{
  "schemaVersion": 1,
  "slug": "binder-design-filtering",
  "name": "binder-design-filtering",
  "description": "Rank and cut de novo protein binder designs before paying to synthesise them — interface confidence from the PAE matrix (ipSAE, ipTM, pDockQ), pLDDT scoped to the binder chain, self-consistency by DockQ, interface geometry and sequence liabilities. Every threshold carries its source, and the filters are scored against a public labelled benchmark of 402 designs.",
  "category": "analysis",
  "version": "1.0.0",
  "author": "Heureka Labs",
  "license": "CC-BY-4.0",
  "tags": [
    "protein-design",
    "binding-affinity",
    "pae",
    "plddt",
    "protein-structure"
  ],
  "updatedAt": "2026-08-27T20:59:55-04:00",
  "source": {
    "repo": "heurekalabsco/heurekaskills",
    "commit": "7e1bad52ac05e02b76eed1a698c07509c64119b5",
    "path": "skills/binder-design-filtering"
  },
  "checksum": "sha256:39e3063b3d0d2453df24b331301bc49b6f00ff005f0d171eef3ca8ad94a5d21e",
  "signals": null,
  "files": [
    {
      "path": "SKILL.md",
      "url": "https://heurekaskills.com/binder-design-filtering/files/SKILL.md",
      "size": 50171,
      "sha256": "399391771520f5bf517b284bd86baaffac2aacb3bcd43975c9b9e584c7212117"
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}